Publications - Van Wolfswinkel lab

Two tiers of piRNA clusters balance diversification of piRNAs with limitation of off-target effects.

Poulet A., Witmer M., Li D., Cathelin R., van Wolfswinkel J.C.

BioRxiv (2026)

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Drift of positional identity drives reproductive aging in a long-lived regenerative animal

Verdesca A., Poulet A., Bales M., van Wolfswinkel J.C.

Current Biology (2026) coming soon

Host-transposon mutualism supports regeneration in planarians

Lee HL., Poulet A., Allikka Parambil S., van Wolfswinkel J.C.

Developmental Cell (2026) coming soon

The sensory basis of planarian behavior

Ascunce Gonzalez K., Lopez S., Carlson J., van Wolfswinkel J.C.

J. Neurosci (2026) coming soon

Enhanced RNA quality control maintains long-term regenerative ability in planarians

Zelko M.*, Li D.*, Allikka Parambil S., Poulet A., Verdesca A., Mazeika K., Dasgupta K., van Wolfswinkel J.C.

Development (2025) 152, 204762, 1-15

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PIWI-interacting RNAs: who, what, when, where, why, and how

Haase A.D., Ketting R.F., Lai E.C., van Rij R.P., Siomi M., Svoboda P., van Wolfswinkel J.C., Wu P.H.

EMBO Journal (2024) 43, 5335-5339

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A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals

Konstantinidou P., Loubalova Z., Ahrend F., Friman A., Almeida M.V., Poulet A., Horvat F., Wang Y., Losert W., Lorenzi H., Svoboda P., Miska E.A., van Wolfswinkel J.C., Haase A.D.

Cell Reports (2024) 43, 114777, 1-23

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piRNA generation is associated with the pioneer round of translation in stem cells

Allikka Parambil S., Li D., Zelko M., Poulet A., van Wolfswinkel J.C.

Nucleic Acids Research (2024) gkad1212, 1-17

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Insights in piRNA targeting rules

van Wolfswinkel J.C.

WIREs RNA (2023) e1811, 1-21

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Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy

Poulet A.*, Kratkiewicz A.J.*, Li D., van Wolfswinkel J.C.

Science Advances 9 (2023) eadh4887, 1-17

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NODeJ: an ImageJ plugin for 3D segmentation of nuclear objects

Dubos T.*, Poulet A.*, Thomson G., Péry E., Chausse F., Tatout C., Desset S.*, van Wolfswinkel J.C.*, Jacob Y.*

BMC Bioinformatics (2022) 23, 216, 1-11

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PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation

Li D., Taylor D.H., van Wolfswinkel J.C.

Cell Reports (2021) 37, 109776, 1-18

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Other Publications

H3.1K27M-induced misregulation of the TSK/TONSL-H3.1 pathway causes genomic instability

Yuan W., Huang Y., LeBlanc C., Poulet A., De Luna Vitorino F.N., Valsakumar D., Dean R., Garcia B.A., van Wolfswinkel J.C., Voigt P., Jacob Y.

Nature Communications (2025) 16, 3547, 1-16

The Histone Chaperone Network Is Highly Conserved in Physarum polycephalum

Poulet A., Rousselot E., Téletchéa S., Noirot C., Jacob Y., van Wolfswinkel J.C., Thiriet C., Duc C.

International Journal of Molecular Sciences (2023) 24:1051, 1-21

MtING2 encodes an ING domain PHD finger protein which affects Medicago growth, flowering, global patterns of H3K4me3, and gene expression

Jaudal M., Mayo‐Smith M., Poulet A., Whibley A., Peng Y., Zhang L., Thomson G., Trimborn L., Jacob Y., van Wolfswinkel J.C., Goldstone D.C., Wen J., Mysore K.S., Putterill J.

The Plant Journal (2022) 112, 1029-1050

A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes

Carmell M.A., Dokshin G.A., Skaletsky H., Hu Y.C., van Wolfswinkel J.C., Igarashi K.J., Bellott D.W., Nefedov M., Reddien P.W., Enders G.C., Uversky V.N., Mello C.C., Page D.C.

eLife (2016) 5, e19993, 1-25

Single cell analysis reveals functionally distinct classes within the planarian stem cell compartment

van Wolfswinkel J.C.*, Wagner D.E.*, Reddien P.W.

Cell Stem Cell (2014) 15, 326-339

Piwi and potency: PIWI proteins in animal stem cells and regeneration

van Wolfswinkel J.C.

Integrative and Comparative Biology (2014) 54, 700-713

Whole-body acoel regeneration is controlled by Wnt and Bmp-Admp signaling

Srivastava M., Mazza K., van Wolfswinkel J.C., Reddien P.W.

Current Biology (2014) 24, 1107-1113

MUT-14 and SMUT-1 DEAD box RNA helicases have overlapping roles in germline RNAi and endogenous siRNA formation

Phillips C.M., Montgomery B.E., Breen P.C., Roovers E.F., Rim Y.S., Ohsumi T.K., Newman M.A., van Wolfswinkel J.C., Ketting R.F., Ruvkun G., Montgomery T.A.

Current Biology (2014) 24, 839-844

Differential impact of the Hen1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans.

Kamminga L.M.*, van Wolfswinkel J.C.*, Luteijn M.J.*, Kaaij L.J.T., Bagijn M.P., Sapetschnig A., Miska E.A., Berezikov E., Ketting R.F.

PLoS Genetics (2012) 8, e1002702, 1-14

The role of small non-coding RNAs in genome stability and chromatin organization.

van Wolfswinkel J.C., Ketting R.F.

Journal of Cell Science (2010) 123, 1825-1839

CDE‑1 affects chromosome segregation through uridylation of CSR‑1-bound siRNAs

van Wolfswinkel J.C., Claycomb J.M., Batista P.J., Mello C.C., Berezikov E., and Ketting R.F.

Cell (2009) 139, 135-148

The Argonaute CSR‑1 and its 22G-RNA cofactors are required for holocentric chromosome segregation

Claycomb J.M., Batista P.J., Pang K.M., Gu W., Vasale J.J., van Wolfswinkel J.C., Chaves D.A., Shirayama M., Mitani S., Ketting R.F., Conte D Jr, Mello C.C.

Cell (2009) 139, 123-134

Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences

Robert V.J., Sijen T., van Wolfswinkel J., and Plasterk R.H.

Genes and Development (2005) 19, 782-787

Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 ,production by a murine and human keratinocyte cell line

Van Och F.M., Van Loveren H., Van Wolfswinkel J.C., Machielsen A.J., and Vandebriel R.J.

Toxicology (2005) 210, 95-109